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Overview

Research in the Lockery Lab spans the spectrum from basic research into fundamental principles of neuronal function to translation research into neglected tropical diseases, aging and neurodegeneration.


Basic research

We seek to understand the neuronal basis of behavior in the nematode worm Caenorhabditis elegans. C. elegans has a small nervous system (302 neurons) whose neurons and connectivity pattern have been completely characterized, providing a unique opportunity to trace the causes of behavior from sensation to action. This work is significant because it is likely to lead to universal principles of neural computation. Focusing on spatial orientation behaviors (esp. chemotaxis) and decision making, the lab's research integrates multiple levels of analysis, from genes to neurons, neurons to networks, and networks to behavior. Eight distinct approaches are brought to bear on the problem: electrophysiology, calcium imaging, optogenetics, microfluidics, quantitative behavioral analysis, laser ablations, and mathematical modeling. Through these efforts, we have identified the mechanism by which C. elegans computes the time derivative of chemosensory input, and the genetic basis of functional asymmetries in a bilaterally symmetrical nervous system. Other work includes development of a stochastic neural network model or random search behavior that correctly predicts the functional connectivity of identified neurons in C. elegans, and the effects of drugs of abuse on economic decision making. Many of these findings have required the development of new techniques and approaches, including the first methods for electrophysiological recordings from C. elegans neurons and for high-resolution calcium imaging in intact, freely moving worms engaged in natural behaviors. This work is funded by the National Institutes of Mental Health.


Translational research

Our translational research concerns the development and commercialization of microfluidic devices for making electrophysiological recordings from C. elegans and parasitic nematodes. A microfluidic device (a.k.a "chip") can be thought of as a miniature plumbing system in which it is possible to precisely control and manipulate fluids that are constrained within small networks of channels, typically sub-millimeter in cross-sectional scale. Importantly, these devices can also be used to manipulate microorganisms such as nematodes. One of our major contributions to the field has been the demonstration that such devices can be adapted for recording electrical signals emitted by nematodes. We have further shown that these recordings can be used in drug development studies to perform initial screens for biological activity of novel compounds, and to discover the mode of action of these compounds. We foresee three main areas of application for these devices: anti-nematode drugs called anthelmintics, drugs for treatment of neuro- and neuromuscular degenerative diseases, and drugs for the amelioration of the effects of aging. The anthelmintic projects have important world-health implications, as more the 2 billion people carry nematode infections. This work is funded by the National Institutes of Health, the Oregon Nano and Microtechnologies Institute, and the Bill and Melinda Gates Foundation. The technology is being commercialized by NemaMetrix, Inc, a University of Oregon spin-out company (nemametrix.com).



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/groups/main/search/index.rss?tag=hotlist/groups/main/search/?tag=hotWhat’s HotHotListHot!?tag=hot4/groups/main/sidebar/HotListshawnShawn Lockery2016-06-13 17:02:44+00:002016-06-13 17:02:44updated26shawnShawn Lockery2016-06-13 17:00:59+00:002016-06-13 17:00:59updated25shawnShawn Lockery2013-06-04 23:28:29+00:002013-06-04 23:28:29updated24shawnShawn Lockery2013-06-04 23:27:01+00:002013-06-04 23:27:01updated23shawnShawn Lockery2013-06-04 23:26:42+00:002013-06-04 23:26:42updated22shawnShawn Lockery2013-06-04 23:22:19+00:002013-06-04 23:22:19updated21shawnShawn Lockery2013-05-29 22:23:50+00:002013-05-29 22:23:50updated20shawnShawn Lockery2013-04-29 21:08:28+00:002013-04-29 21:08:28updated19katKat McCormick2012-11-15 19:58:04+00:002012-11-15 19:58:04updated18katKat McCormick2012-11-15 19:54:59+00:002012-11-15 19:54:59updated17Added tag - hotshawnShawn Lockery2012-11-15 19:54:57+00:002012-11-15 19:54:57addTag16shawnShawn Lockery2012-09-19 22:04:44+00:002012-09-19 22:04:44updated15shawnShawn Lockery2012-09-19 19:47:46+00:002012-09-19 19:47:46updated14shawnShawn Lockery2012-09-19 19:45:52+00:002012-09-19 19:45:52updated13shawnShawn Lockery2012-09-19 19:42:31+00:002012-09-19 19:42:31updated12shawnShawn Lockery2012-09-19 19:37:46+00:002012-09-19 19:37:46updated11shawnShawn Lockery2009-12-17 06:43:01+00:002009-12-17 06:43:01updated10eduardoEduardo Izquierdo2009-12-10 19:24:04+00:002009-12-10 19:24:04updated9eduardoEduardo Izquierdo2009-12-10 19:22:14+00:002009-12-10 19:22:14updated8eduardoEduardo Izquierdo2009-12-10 19:19:09+00:002009-12-10 19:19:09updated7eduardoEduardo Izquierdo2009-12-10 19:19:07+00:002009-12-10 19:19:07updated6eduardoEduardo Izquierdo2009-12-02 03:41:26+00:002009-12-02 03:41:26updated5eduardoEduardo Izquierdo2009-12-02 02:15:20+00:002009-12-02 02:15:20updated4eduardoEduardo Izquierdo2009-12-02 02:13:15+00:002009-12-02 02:13:15updated3eduardoEduardo Izquierdo2009-12-01 23:48:09+00:002009-12-01 23:48:09updated2First creatededuardoEduardo Izquierdo2009-12-01 23:48:04+00:002009-12-01 23:48:04created1wiki2016-06-13T17:02:44+00:00groups/main/wiki/a99e9FalseResearch/groups/main/wiki/a99e9/Research.htmlShawn Lockery26 updatesResearch Home | Research | Publications | People | Resources | Contact [image] [Research-medalian.png] Overview Research in the Lockery ...Falseshawn2016-06-13T17:02:44+00:00shawnShawn Lockery2014-07-11 01:12:07+00:002014-07-11 01:12:07updated20Added tag - hotshawnShawn Lockery2012-11-15 19:58:50+00:002012-11-15 19:58:50addTag19shawnShawn Lockery2012-11-14 19:45:32+00:002012-11-14 19:45:32updated18shawnShawn Lockery2012-11-14 19:44:51+00:002012-11-14 19:44:51updated17shawnShawn Lockery2012-11-14 19:41:58+00:002012-11-14 19:41:58updated16shawnShawn Lockery2012-11-14 19:41:02+00:002012-11-14 19:41:02updated15shawnShawn Lockery2012-11-14 19:40:55+00:002012-11-14 19:40:55updated14shawnShawn Lockery2012-11-14 19:40:22+00:002012-11-14 19:40:22updated13shawnShawn Lockery2012-11-14 19:39:44+00:002012-11-14 19:39:44updated12shawnShawn Lockery2012-11-14 19:29:56+00:002012-11-14 19:29:56updated11shawnShawn Lockery2012-11-14 19:29:47+00:002012-11-14 19:29:47updated10shawnShawn Lockery2012-10-05 19:22:06+00:002012-10-05 19:22:06updated9shawnShawn Lockery2012-09-19 19:10:28+00:002012-09-19 19:10:28updated8shawnShawn Lockery2012-09-19 18:42:43+00:002012-09-19 18:42:43updated7shawnShawn Lockery2009-12-17 06:44:14+00:002009-12-17 06:44:14updated6shawnShawn Lockery2009-12-17 06:22:50+00:002009-12-17 06:22:50updated5shawnShawn Lockery2009-12-17 06:21:47+00:002009-12-17 06:21:47updated4eduardoEduardo Izquierdo2009-12-10 19:20:22+00:002009-12-10 19:20:22updated3eduardoEduardo Izquierdo2009-12-02 03:34:14+00:002009-12-02 03:34:14updated2First creatededuardoEduardo Izquierdo2009-12-02 03:34:08+00:002009-12-02 03:34:08created1wiki2014-07-11T01:12:07+00:00groups/main/wiki/a4878FalseResources/groups/main/wiki/a4878/Resources.htmlShawn Lockery20 updatesResourcesHome | Research | Publications | People | Resources | Contact Wisdom Neuron-specific promoters (curated list) Graphics needed for this p...Falseshawn2014-07-11T01:12:07+00:00shawnShawn Lockery2014-03-02 21:01:41+00:002014-03-02 21:01:41updated12Added tag - hotlablab2012-11-15 19:58:41+00:002012-11-15 19:58:41addTag11lablab2012-09-19 20:34:24+00:002012-09-19 20:34:24updated10shawnShawn Lockery2009-12-17 06:43:35+00:002009-12-17 06:43:35updated9shawnShawn Lockery2009-12-17 06:43:12+00:002009-12-17 06:43:12updated8eduardoEduardo Izquierdo2009-12-15 00:39:08+00:002009-12-15 00:39:08updated7eduardoEduardo Izquierdo2009-12-10 19:26:54+00:002009-12-10 19:26:54updated6eduardoEduardo Izquierdo2009-12-10 19:24:47+00:002009-12-10 19:24:47updated5eduardoEduardo Izquierdo2009-12-10 19:23:21+00:002009-12-10 19:23:21updated4eduardoEduardo Izquierdo2009-12-10 19:18:50+00:002009-12-10 19:18:50updated3eduardoEduardo Izquierdo2009-12-10 19:18:00+00:002009-12-10 19:18:00updated2First creatededuardoEduardo Izquierdo2009-12-10 19:17:53+00:002009-12-10 19:17:53created1wiki2014-03-02T21:01:41+00:00groups/main/wiki/55fd9FalsePublications/groups/main/wiki/55fd9/Publications.htmlShawn Lockery12 updatesPublications Home | Research | Publications | People | Resources | Contact 1: Connolly AA, Osterberg V, Christensen S, Price M, Lu C, Chicas-...Falseshawn2014-03-02T21:01:41+00:00katKat McCormick2013-09-29 02:14:38+00:002013-09-29 02:14:38updated30Added tag - hotabekatzenAbe Katzen2012-11-15 19:58:56+00:002012-11-15 19:58:56addTag29abekatzenAbe Katzen2012-11-14 20:48:10+00:002012-11-14 20:48:10updated28abekatzenAbe Katzen2012-11-14 20:43:26+00:002012-11-14 20:43:26updated27lablab2012-09-19 20:14:29+00:002012-09-19 20:14:29updated26shawnShawn Lockery2012-09-19 19:11:35+00:002012-09-19 19:11:35updated25abekatzenAbe Katzen2012-09-06 19:44:21+00:002012-09-06 19:44:21updated24abekatzenAbe Katzen2012-09-06 19:29:47+00:002012-09-06 19:29:47updated23abekatzenAbe Katzen2012-09-05 20:48:27+00:002012-09-05 20:48:27updated22shawnShawn Lockery2009-12-17 06:48:14+00:002009-12-17 06:48:14updated21shawnShawn Lockery2009-12-17 06:48:01+00:002009-12-17 06:48:01updated20shawnShawn Lockery2009-12-17 06:46:42+00:002009-12-17 06:46:42updated19shawnShawn Lockery2009-12-17 06:44:52+00:002009-12-17 06:44:52updated18shawnShawn Lockery2009-12-17 06:41:48+00:002009-12-17 06:41:48updated17shawnShawn Lockery2009-12-17 06:41:27+00:002009-12-17 06:41:27updated16shawnShawn Lockery2009-12-17 06:41:06+00:002009-12-17 06:41:06updated15shawnShawn Lockery2009-12-17 06:40:45+00:002009-12-17 06:40:45updated14shawnShawn Lockery2009-12-17 06:40:21+00:002009-12-17 06:40:21updated13shawnShawn Lockery2009-12-17 06:38:06+00:002009-12-17 06:38:06updated12shawnShawn Lockery2009-12-17 06:37:46+00:002009-12-17 06:37:46updated11shawnShawn Lockery2009-12-17 06:34:04+00:002009-12-17 06:34:04updated10shawnShawn Lockery2009-12-17 06:32:14+00:002009-12-17 06:32:14updated9shawnShawn Lockery2009-12-17 06:31:07+00:002009-12-17 06:31:07updated8shawnShawn Lockery2009-12-17 06:28:59+00:002009-12-17 06:28:59updated7shawnShawn Lockery2009-12-17 06:28:28+00:002009-12-17 06:28:28updated6shawnShawn Lockery2009-12-17 06:28:01+00:002009-12-17 06:28:01updated5shawnShawn Lockery2009-12-17 06:27:22+00:002009-12-17 06:27:22updated4shawnShawn Lockery2009-12-17 06:27:00+00:002009-12-17 06:27:00updated3shawnShawn Lockery2009-12-17 06:26:29+00:002009-12-17 06:26:29updated2First createdshawnShawn Lockery2009-12-17 06:25:37+00:002009-12-17 06:25:37created1wiki2013-09-29T02:14:38+00:00groups/main/wiki/52c6aFalseContact/groups/main/wiki/52c6a/Contact.htmlKat McCormick30 updatesContactHome | Research | Publications | People | Resources | Contact Shawn Lockery Principle Investigator ...Falsekat2013-09-29T02:14:38+00:00hot/groups/main/search/index.rss?sort=modifiedDate&kind=all&sortDirection=reverse&excludePages=wiki/welcomelist/groups/main/search/?sort=modifiedDate&kind=all&sortDirection=reverse&excludePages=wiki/welcomeRecent ChangesRecentChangesListUpdates?sort=modifiedDate&kind=all&sortDirection=reverse&excludePages=wiki/welcome0/groups/main/sidebar/RecentChangesListmodifiedDateallRecent ChangesRecentChangesListUpdateswiki/welcomeNo recent changes.reverse5search